PMTCT & Malaria
OBJECTIVES
To determine the prevalence and correlates of placental malaria in HIV1 infected and non-infected women, the effect of placental malaria on viral shedding in the genital tract, and the impact of placental malaria on perinatal HIV1 transmission
METHODS
Placental histology was used for detection of malaria parasites
ACTIVITIES
Newborns were tested for HIV1-PCR at 1 day and 6 weeks after birth
RESULTS
Malaria parasites were found in 9.1 % (34/372) of the HIV1 infected mothers and in 4.3 % (12/277) of HIV1 non-infected women (p= 0.018). No association was found between placental malaria and maternal viral load, or genital tract HIV1-DNA and RNA. Placental malaria did not correlate with in utero (2.9 versus 5.6%, p=0.509) nor peripartal HIV1 transmission (11.5 versus 15.4%, p=0.602)
Funding agencies
European Commission
Team
Ingrid Inion, Eric Van Marck, Cris Verhofstede, Els Goetghebeur, Kishorchandra Mandaliya, Fabian Mwanyumba, Marleen Temmerman
Partners
ICRH, University of Ghent Obstetrics and ICRH, University of Ghent Pathology; University of Antwerp HIV Reference Laboratory; University of Ghent Applied Mathematics; University of Ghent Coast Provincial General Hospital, Mombasa
Period
January 06, 2001 - August 31, 2001
Project status
Project closed